Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients

Xue WEN; Xuan CHEN; Xiaoping CHENG

doi:10.5137/1019-5149.JTN.21840-17.4

Issue release date: 12.11.2024

Current Issue

Ahead Of Print

Archive

Subscription for Hardcopy

Turkish Neurosurgery 2020 , Vol 30 , Num 1

Abstract PDF Similar Articles Mail to Author

Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients

Xue WEN¹,Xuan CHEN¹,Xiaoping CHENG¹

¹Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan 432000, China DOI : 10.5137/1019-5149.JTN.21840-17.4 AIM: To evaluate the over expression of Glucose-regulated protein 78 kda (GRP78) in recurrent glioblastoma multiforme (GBM) and explore its chemoresatance.

MATERIAL and METHODS: Western blot analysis and real-time PCR were done to detect the expression of GRP78 in GBM tissues.

RESULTS: It was detected that GRP78 is up-expressed in GBM, especially in recurrent GBM. Radiotherapy (RT) plus temozolomide chemotherapy after primary tumor removal in relapsed patients induces C/EBP homologous protein (CHOP).

CONCLUSION: The results mentioned above illustrate an essential function of GRP78 in the pathogenesis of GBM and suggest this receptor as the latest prognostic marker for further GRP78-targeted molecular cancer therapy and potential diagnosis of GMB. Keywords : Glioma, Temozolomide, Glucose-regulated protein 78 kda, Chemotherapy

Corresponding author : Xue WEN, wenxue791203@163.com