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¹Trakya University Medical Faculty. Department of Neurosurgery – EDİRNE
²Istanbul Medical Faculty. Department of Histology and Embryology - İSTANBUL In a modified LEVINE preparation, the effects of mannitol dexamethasone alone and in combination in hypoxic-ischemic brain insults were studied by electron microscopy in which dexamethasone appeared to be more effective than mannitol or its combination with mannitol in reducing ischemic swelling and protecting the neural integrity. Keywords : Rat, Electron microscopy, Ischemic edema, Dexamethasone, Mannitol