Amyloidosis is a progressive disorder marked by the deposition of insoluble fibrillar proteins that aggregate in various tissues, leading to tissue damage. Localized amyloidosis, known as amyloidoma, is particularly rare in the central nervous system and may be mistaken for neoplastic lesions due to similar radiological features. Consequently, the general approach often involves total excision. However, it is important to consider that biopsy of amyloidomas, rather than total excision, may be sufficient for complete recovery when paired with appropriate systemic treatment. This report presents two rare cases of amyloidoma: one located in the falx cerebri and the other in the lumbar spine. Both cases were successfully operated on, with patients recovering without complications following treatment. (4)