Aim:To investigate the protective and therapeutic effects of dexpanthenol in experimental global cerebral ischemia-reperfusion injury
Material and Methods:32 female Wistar-Albino rats were used and the rats were divided into 4 groups (Sham, Ischaemia Reperfusion (IR), IR+Dexpantol (IR+DXP) and DXP+IR), each containing 8 animals. At the end of 72 hours of reperfusion, the rats were decapitated after performing the rota-rod and acceler-rod tests, and their brain tissues were removed, histopathologically examined and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malonyldialdehyde (MDA) levels were evaluated.
Results:In this study, motor skill functions deteriorated in the ischemia-reperfusion (IR) group compared to the Sham group, while significant improvements were observed in both the IR + DXP and DXP + IR groups (p<0.05). There were no notable differences in CAT, SOD, and GPx enzyme levels among the groups (p>0.05). However, malondialdehyde (MDA) levels increased in the IR group but decreased significantly in the IR + DXP group (p<0.05). Similarly, glutathione (GSH) levels were lower in the IR group but higher in the IR + DXP group (p<0.05). Neuronal degeneration also significantly increased in the IR group, but decreased in the IR + DXP group (p<0.05).
Conclusion:Overall, these findings suggest that dexpanthenol has a neuroprotective effect, particularly when administered during the reperfusion phase, effectively improving motor skills and reducing neuronal damage
