Aim:Primary Central Nervous System Lymphoma (PCNSL) is rare and the prognosis is poor. In this study, we aimed to evaluate the relationship between the most commonly used defined scoring systems/some parameters and prognosis in our patient group diagnosed with PCNSL.Material and Methods:Clinical information was collected from patients diagnosed with PCNSL between 2013 and 2024. In addition to previously defined and validated scoring systems (the International Extranodal Lymphoma Study Group (IELSG), the Nottingham/Barcelona (NB), and the Memorial Sloan-Kettering Cancer Center models (MSKCC), we also evaluated some newly defined parameters. The predictive significance of all assessments for overall survival was investigated.Results:A total of 37 patients were diagnosed with PSSSL. We could not determine the IELSG model due to missing data. The MSKCC groups were not associated with mortality. According to Kaplan-Meier test, age, Karnofsky performance status (KPS) score and NB score had a significant effect on survival (Long-rank= 0.002, <0.001, and 0.006; respectively). The cut-off value for KPS score was determined as 85 points according to ROC analysis. The cut-off value for age was determined as 59 years. KPS< 85 ve yaş ≥ 60 years were determined as poor prognostic. This grouping with KPS and age variables was significant according to Kaplan-Meier survival analysis (Long Rank= 0.023). Mortality was significantly higher in patients fulfilling the KPS < 85 and Age ≥ 60 conditions (50.0 vs 88.9%, p= 0.011, Odd\'s Ratio: 8.0, CI95%: 1.4- 45.4).Conclusion:This study was conducted in a single-center, under the conditions of our country\'s health system. As in other classification recommendations, performance score and age were the most important survival determinants. We were able to classify according to the NB model and found that it was significant in terms of survival.