Non-neoplastic intracranial cysts (NICCs) are usually stable and typically do not cause symptoms throughout life. Among the various NICCs, rare spontaneous disappearances of arachnoid cysts, colloid cysts, and Rathke\'s cleft cysts in various locations have been reported. To our knowledge, no reports to date have described spontaneous disappearance of choroid plexus cysts (CPCs). We here report the first case of spontaneous bilateral disappearance of CPCs. Although the exact pathogenic mechanisms remain unclear, we believe that a sudden transient change in intracranial pressure or cerebrospinal fluid circulation plays an important role in the bilateral disappearance of CPCs. Further research is warranted to clarify this rare phenomenon.