Turkish Neurosurgery
Investigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model
Guven Akcay1, Fikri Ozdemir2, Sevil Ozkinali3, Filiz Demirdogen4, Ali Yılmaz5, Cagla Celik6
1Hitit University, Faculty of Medicine, Department of Biophysics, Çorum,
2Hitit University, Faculty of Medicine, tment of Anatomy, Çorum,
3Hitit University, Faculty of Arts and Sciences, Department of Chemistry, Çorum,
4Binali Yıldırım University, Mengücek Gazi Education and Research Hospital, Department of Neurology, Erzincan,
5Ordu University, Faculty of Medicine, Department of Neurosurgery, Ordu,
6Hitit University, Vocational School of Health Services, Çorum,
DOI: 10.5137/1019-5149.JTN.46057-23.7
Aim:Mild traumatic brain injury (mTBI) constitutes a serious neurological condition. This study examined the effects of phenolic compound-rich ginger extract on motor and cognitive functions as well as cytokine levels in the mTBI model.Material and Methods:The mTBI model was modeled employing the Marmarou method. The Ginger group rats were i.p. administered 50 mg/kg of ginger extract. The Ginger+traumatic brain injury (TBI) group rats were i.p. administered 50 mg/kg of ginger extract two days before the TBI was induced. The control and TBI+Ginger group rats were provided ginger extract (50 mg/kg i.p.) immediately after the TBI. Motor and cognitive behavioral experiments were performed. The cytokine levels were analyzed using the ELISA method.Results:While TBI caused a decline in motor and cognitive functions, significant enhancements of these functions were observed in the Ginger+TBI and TBI+Ginger groups because of the ginger treatment. While TBI induced an increased hippocampal cytokine level, significant decreases were detected in the Ginger+TBI and TBI+Ginger groups following ginger treatment.Conclusion:The study findings revealed that phenolic compound-rich ginger extract may exert therapeutic effects on cytokine levels in the mTBI model.
Corresponding author : Guven Akcay