Turkish Neurosurgery
RELATIONSHIP BETWEEN DEFECTVOLUME AND COMORBID PATHOLOGIES IN PATIENTS UNDERGOING SURGERY FOR MYELOMENINGOCELE
Zeliha Çulcu Gürcan1, Haydar Çelik2, Yavuz Erdem2, Ayhan Tekiner2, Dilek Kahvecioğlu7, Berkay Ayhan3, Serdar Cengiz5, Burak Yürük4, Kemal Kantarcı6, Tuncer Taşcıoğlu2, Mehmet Emre Yıldırım2, Hakan Gürcan8, Ömer Şahin2
1Sincan Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahi, Ankara,
2Ankara Eğitim ve Araştırma Hastanesi, beyin ve sinir cerrahisi kliniği, Ankara,
3Düzce Atatürk Devlet Hastanesi, Beyin ve Sinir Cerrahisi, Düzce,
4Niğde Ömer Halisdemir Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahisi, Niğde,
5Özel Genesis Hastanesi, Beyin ve Sinir Cerrahisi, Diyarbakır,
6Hatay Eğitim ve Araştırma Hastanesi, Beyin ve Sinir Cerrahisi, Hatay,
7Ankara Eğitim ve Araştırma Hastanesi, Neonataloji , Ankara,
8Dr.Sami Ulus Çocuk Sağlığı Hastalıkları Eğitim ve Araştırma Hastanesi, Pediatri ABD, Ankara,
DOI: 10.5137/1019-5149.JTN.46011-23.3
Aim:The aim of the study is to determine sac volume based on radiological examinations in patients undergoing surgery for myelomeningocele (MMC) and to investigate the relationship of sac volume with hydrocephalus and Chiari malformation type 2 (CM) with a view to determining the optimum length of follow-up and recommend a treatment plan. Material and Methods:The present study involved the retrospective review of radiologic examinations and medical files of 81 patients who underwent surgery for myelomeningocele between 2015 and 2022 in the neurosurgery clinic of Ankara Training and Research Hospital. Then, MMC sac volumes were measured and the statistical relationship of these measurements with the Evans Index, progressive enlargement of the ventricles after sac repair and CM was investigated. Results:Of the 81 patients, 41(50.6%) were boys and 40(49.4%) were girls. The median MMC sac volume was 11,005.28 mm³ and the mean Evans index (EI) based on brain tomography performed on postnatal day1was 0.405 ± 0.146. Analysis of the relationship between the EI and MMC sac volume yielded r=0.622, p<0.001 and showed a strong positive correlation between the two parameters at a statistical significance level of 5%. Evans Indexes based on brain tomography scans performed on postnatal day 1 showed that ventriculomegaly was present in 49(60.5%) patients and absent in 32(39.5%) patients. Of the 81 patients, 48(59.3%) underwent shunting and the remaining 33(40.7%) patients did not require shunting. 28 patients underwent shunting simultaneously with the sac repair, i.e., on day 12 on average, while 20 patients exhibited a progressive increase in their EI after sac repair and required a second surgery for shunting on day 28 on average. The mean MMC sac volume was 11,511.214 mm³ in 20 patients who subsequently developed hydrocephalus versus 3,066.9997 mm³ in patients who did not require shunting before or after sac repair. In patients who developed hydrocephalus after sac repair, there was no correlation between the day of intervention and sac volume. Mean sac volume was 28,297.36 mm³ in 28 patients with comorbid CM versus 7,600.32mm³ in patients without CM. All children with CM required shunting.Conclusion:Patients with larger myelomeningocele sac volume have higher risk of concomitant hydrocephalus or subsequent development of hydrocephalus after sac repair compared to patients with a smaller sac volume. These patients should definitely be evaluated for same-session intervention. Patients with a larger sac volume and/or comorbid CM should be followed up more frequently and for a longer period of time.
Corresponding author : Zeliha Çulcu Gürcan