Turkish Neurosurgery 2020 , Vol 30 , Num 5
The Effect of Indicators of Systemic Inflammatory Response on Survival in Glioblastoma Multiforme
Ozlem MERMUT1,Berrin INANC1
1University of Health Sciences, Istanbul Training and Research Hospital, Clinic of Radiation Oncology, Istanbul, Turkey DOI : 10.5137/1019-5149.JTN.27068-19.1 AIM: To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastoma multiforme patients.

MATERIAL and METHODS: A total of 75 patients retrospectively analysed. The complete blood count of the patients was analysed before surgery. In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) were found to be significant by creating the ROC curve. Overall survival (OS) was calculated from surgery to death or the last contact. Progression-free survival (PFS) was calculated from surgery to progression. The last follow-up was November 2018.

RESULTS: The median OS was significantly shorter in PLR>150 patients (p=0.005; 10 vs 17 months). And the median OS was significantly shorter in NLR>4 patients too (p=0.010; 11 vs 17 months). In multivariate analysis, Karnofsky performance score <70 (HR:2.96, 95% CI:1.68-5.21; p<0.001), type of surgical resection (HR:2.32, 95% CI:1.35-3.98; p=0.002) were statistically significant for PFS. In multivariate analysis, KPS<70 (HR:2.72, 95% CI:1.30-5.67; p<0.007), type of surgical resection (HR:2.09, 95% CI:1.10- 3.95; p=0.023), NLR>4 (HR:2.14, 95% CI:1.11-4.14; p=0.023) were statistically significant for OS were found to be independent prognostic factor.

CONCLUSION: The presence of 704, 70 Keywords : Glioblastoma multiforme, Pretreatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, Survival

Corresponding author : Ozlem MERMUT, mermutozlem@gmail.com