Effects of 4% Icodextrin on Experimental Spinal Epidural Fibrosis
AIM: The aim of this experimental study was to investigate whether spinal epidural 4% glucose polymer solution is effective in the
prevention of postoperative fibrosis.
MATERIAL and METHODS: Twenty eight adult Wistar albino rats were randomly divided into two equal groups, including treatment
and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. Topical treatment group received 4%
icodextrin. Four weeks later, epidural fibrosis was examined in both groups histologically, biochemically and macroscopically.
RESULTS: Topical use of 4% icodextrin prevented significantly epidural fibrosis following the laminectomy operation.
CONCLUSION: Topical 4% icodextrin application inhibits postoperative epidural fibrosis with various mechanisms and prevents
adhesions by playing barrier role between tissue surfaces through flotation. Our study is first to present evidence of experimental
epidural fibrosis prevention with 4% icodextrin.