Issue release date: 12.11.2024
2Shandong University, Qilu Hospital, Jinan Shandong, China
3Shandong University, College of Pharmacy, Jinan Shandong, China DOI : 10.5137/1019-5149.JTN.4055-10.1 AIM: NKN reduces brain edema, neuronal death and neurological deficits in rats after cerebral ischemia. In the present study, we investigated whether NKN was effective on brain injury in cerebral ischemia rats.
MATERIAL and METHODS: The middle cerebral artery occlusion (MCAO) model was used to produce experimental cerebral ischemia in adult male Wistar rats. The activity of SOD and concentration of MDA were determined. We also examined the efficacy of NKN on neurological deficit scores, expression of N-methyl-D-aspartate receptor and endothelin-1 mRNA in brain of focal cerebral ischemia rats.
RESULTS: The results show that NKN significantly increased the activity of SOD, decreased the concentration of MDA, decreased neurological deficit scores, inhibited the expression of N-methyl-D-aspartate receptor and endothelin-1 mRNA in brain of focal cerebral ischemia rats.
CONCLUSION: The results implied NKN could protect brain against injury caused by cerebral ischemia.
Keywords : NKN, Cerebral ischemia, Neurological deficit scores, SOD, MDA, NMDAR, ET-1mRNA