Issue release date: 12.11.2024

 
Turkish Neurosurgery 2011 , Vol 21 , Num 4
The Effect of Degenerated Neuron Density of Petrosal Ganglion on the Development of Blood Pressure Variabilities after Subarachnoid Hemorrhage in a Rabbit Model: An Experimental Study
Ahmet Murat MUSLUMAN1, Mehmet Dumlu AYDIN2, Adem YILMAZ1, Tufan CANSEVER3, Ayhan KANAT4, Cemal GUNDOGDU5, Zeynep CAKIR6, Mucahit EMET6, Nesrin GURSAN5, Nazan AYDIN7, Bunyamin UNAL8
1Sisli Research and Education Hospital, Department of Neurosurgery, Istanbul Turkey
2Ataturk University, Medical School, Department of Neurosurgery, Erzurum, Turkey
3Baskent University, Istanbul Hospital, Department of Neurosurgery, İstanbul Turkey
4Rize University, Medical School, Department of Neurosurgery, Rize,Turkey
5Ataturk University, Medical School, Department of Pathology, Erzurum, Turkey
6Ataturk University, Medical School, Department of Emergency, Erzurum, Turkey
7Ataturk University, Medical School, Department of Psychiatry, Erzurum, Turkey
8Ataturk University, Medical School, Department of Histology, Erzurum, Turkey DOI : 10.5137/1019-5149.JTN .4553-11.1 AIM: The aim of this study was to determine the relationship between ischemic neurodegeneration, of the petrosal ganglion of the glossopharyngeal nerve, and BP fluctuations, after subarachnoid hemorrhage (SAH).

MATERIAL and METHODS: Twenty-four rabbits had their blood pressure and heart rhythms studied daily over 20 days. Then, the histopathology of the petrosal ganglion was examined in all animals. Normal and apoptotic neuron density of the petrosal ganglion and blood pressure values were compared statistically.

RESULTS: Mean total volume of the petrosal ganglia was calculated as 0.9±0.34/mm3. BP level of control group was 96.1±2.1mmHg; 116.5±4mmHg of mild hypertension (HT) group and 128.1±3.6mmHg in the severe HT group. When the groups were compared to each other they were significantly different. The level of normal-apoptotic neuron in control group was 11240±802/mm3-40±6.3/mm3; 9730±148.7/mm3- 1560±256.2/mm3 in the mild HT group and 6870±378.8/mm3-4240±628.2/mm3 in the severe HT group. When the groups were compared to each other there was significantly difference.

CONCLUSION: Blood pressure variability observed in this study may be explained by ischemic neurodegeneration of petrosal ganglia caused by SAH. The results of this study suggest that petrosal ganglion ischemia has potential implications for the development of hypertension. These findings suggest that new treatment strategies should be considered for the treatment of SAH. Keywords : Glossopharyngeal nerve, Petrosal ganglion, Neuron density, Blood pressure, Subarachnoid hemorrhage

Corresponding author : Mehmet Dumlu Aydın, nmda11@hotmail.com