Issue release date: 12.11.2024
2Department of Neurosurgery, SKIMS, Kashmir, 190011, India
3Department of Medical Oncology, SKIMS, Kashmir, 190011, India
4Department of Radiotherapy, SKIMS, Kashmir, 190011, India DOI : 10.5137/1019-5149.JTN.3100-10.2 AIM: To study the clinicopathological aspects of primary CNS lymphoma in immunocompetent patients.
MATERIAL and METHODS: Sixteen patients with primary CNS lymphoma were analyzed for their clinico-pathological characteristics and followed-up for the treatment and subsequent management in Neurosurgery, and Medical and Radiation Oncology.
RESULTS: The fronto-parietal region was the commonest location of CNS lymphoma; four cases of cerebellar lymphoma were seen. Our patients were relatively young with a mean age of 48 years and an age range of 35-60 years. Females outnumbered males with a ratio of 2.7:1. The commonest presentation was focal neurological-deficits and features of raised intracranial pressure. All the patients histologically had diffuse large B-cell lymphoma. Radiologically, most presented as disc-enhancing lesions. Two patients had multiple lesions. Most of the patients (10) died within a mean of 4.4 months (range 2 weeks-16 months).
CONCLUSION: Primary CNS lymphoma is seen in immunocompetent patients as well. Relapse is common after treatment and the overall prognosis is unfavorable.
Keywords : Primary CNS lymphoma, Immunocompetent, Brain tumor