Turkish Neurosurgery 2008 , Vol 18 , Num 1
Hereditary Neuropathy with Liability to Pressure Palsies in a Turkish Patient (HNPP): A Rare Cause of Entrapment Neuropathies in Young Adults
Yahya ÇELİK1, Cumhur KILINÇER2, M. Kemal HAMAMCIOĞLU3, Kemal BALCI4, Barış BİRGİLİ5, Sebahattin ÇOBANOĞLU6, Ufuk UTKU7
1,3,7Trakya University School of Medicine Neurology, Edirne, Turkey
2,4,5,6Trakya University School of Medicine Neurosurgery Departments, Edirne, Turkey
Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant nerve disease usually caused by 1,5 Mb deletion on chromosome 17p11.2.2-p12, the region where the PMP-22 gene is located. The patients with HNPP usually have relapsing and remitting entrapment neuropathies due to compression. We present a 14-year-old male who had acute onset, right-sided ulnar nerve entrapment at the elbow. He had electrophysiological findings of bilateral ulnar nerve entrapments (more severe at the right side) at the elbow and bilateral median nerve entrapment at the wrist. Genetic tests of the patient demonstrated deletions in the 17p11.2 region. The patient underwent decompressive surgery for ulnar nerve entrapment at the elbow and completely recovered two months after the event. Although HNPP is extremely rare, it should be taken into consideration in young adults with entrapment neuropathies. Keywords : HNPP, Entrapment neuropathy, DNA analysis
Corresponding author : Yahya Çelik, celikyahyatr@yahoo.com