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¹Department of Neurosurgery, School of Medicine, Baskent University, Ankara, Turkey
²Department of Medical Biology and Genetics, School of Medicine, Baskent University, Ankara, Turkey Primary central nervous system lymphomas are rare tumors that account for less than 2% of primary intracerebral neoplasms. A 70-year-old male who had been operated for prostatic adenocarcinoma ten months ago was admitted with the complaint of amnesia, confusion, stupor and difficulty in walking. Magnetic resonance imaging revealed three mass lesions located in the right anterior temporal lobe, at the mesencephalon left cerebral peduncle and at the right frontal cortex. He was operated and the mass lesion at the right anterior temporal lobe was totally excised. Histopathological examination revealed malignant lymphoma of B cell origin. He was given chemotherapy and radiotherapy. Cytogenetic studies were performed on tissue sections obtained from brain lymphoma and prostate tissues of the patient in order to investigate whether a common genetic abnormality had caused both pathologies. The 1p36 and 22qter regions were studied by fluorescent in situ hybridization analyses in order to detect rearrangements of the regions. 1p36 deletion was detected in the prostate cancer tissue sections of the patient. In the brain tissue specimens, there were normal signals after hybridization with the 1p36 probe and deletion in the 22qter region after hybridization with the 22qter probe. We concluded that these two types of tumors had developed independently. Keywords : Cytogenetic, fluorescent in situ hybridization, primary intracerebral lymphoma, prostate adenocancer