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¹GATA Haydarpaşa Training Hospital, Department of Neurosurgery, İstanbul Türkiye
²GATA Haydarpaşa Training Hospital, Department of Undersea and Hyperbaric Medicine, İstanbul Türkiye
³GATA Haydarpaşa Training Hospital, Department of Pathology, İstanbul Türkiye In fetal neural tissue transplantation, lack of oxygen supply to the graft in the acute stage is an important problem. This study evaluated the effects of hyperbaric oxygen treatment on fetal spinal cord grafts. Spinal cord tissues obtained from 16-day fetal rats were transplanted to the spinal cord of adult Wistar rats (n=30). The hosts were then divided into two. groups. Group 1 were untreated controls, and Group 2 rats received 100% O2 at 2.5 atmospheres pressure for 90 minutes twice a day for 7 days. All animals were sacrificed for histological examination. Degenerative changes, interface, host spinal cord edema, and vascularization of the graft were scored on three-grade scales, and the scores were statistically analyzed. The graft survival rates in Groups 1 and 2 were 46.1 % and 71.4%, respectively. Animals treated with HBO showed statistically less spinal cord edema than the untreated group (P < 0.05). The interface was also significantly better in the treated group (P< 0.05). These findings indicate that HBO therapy can increase the chances of graft survival. We believe that the edema-reducing effect of HBO prevented the graft from becoming displaced and, thus, contributed to the successful integration of graft and host. Keywords : Fetal graft; hyperbaric oxygen; neural transplantation; rat; spinal cord