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¹Celal Bayar University School of Medicine Departments of Neurosurgery, Manisa, Turkey
² Celal Bayar University School of Medicine Departments of Physiology, Manisa, Turkey
³Trakya University Schoolof Medicine Department of Pathology,Edirne, Turkey Our previous study showed that epileptic seizures induced by DL-methionine DL-sulfoximine administration to rats could be prevented and Tl relaxation time shortened as a sign of avoiding the brain edema fluid by prior administration of an antioxidant vitamin E. This present study also consisted of three randomized groups: The first was the control group, the second the epilepsy group, the third the prophylaxis group. In each group seven male swiss albino rats of the same age and similar weight were used. In all of the animals in the second-epilepsy group, epileptic generalized seizures were induced pharmacologically by DL-methionine DL-sulfoximine i.v .. In the third prophylaxis group, alpha-tocopherol ( vitamin E ) was intravenously given fifteen minutes before injecting the same epileptic agent of the same dose. None of the animals in this third group developed any convulsions. Thirty minutes after the application of the epileptic agent, all rats in the last two groups were decapitated. The cerebral hemispheric tissue removed from the same site was histologically investigated in all animals of each group by an electron microscope. The clinical as well as neuropathological outcome confirmed that the DL-methionine DL-suIfoximine-induced epileptic activity could be arrested and epileptic cell and tissue damage could be prevented by prophylactic administration of vitamin E. Keywords : Epilepsy, glutamate, epileptic cell damage, electron microscope, vitamin E