MATERIAL and METHODS: The guiding question focused on the epidemiological characteristics of xanthomatous meningiomas. Inclusion criteria encompassed case reports or series detailing patient sex, age, and tumor location. A literature search identified 56 articles on Pubmed and Mendeley. Study selection involved independent screening by two researchers, adhering to predefined criteria. Data collection from eligible studies included patient demographics, symptoms, MRI characteristics, and immunohistochemical markers. Statistical analysis employed SPSS software for nominal qualitative and quantitative variables.

RESULTS: The case report involved a 44-year-old female presenting with disorientation and chronic headache, diagnosed with xanthomatous meningioma. The systematic review incorporated 21 studies and 27 patients, with a female predominance (55.2%) and an average age of 48.2 years. Most tumors were located in the frontal region (57.2%). Common symptoms included headache (21.4%) and seizures (14.2%). Recurrence occurred in only 7.6% of cases, emphasizing the favorable prognosis post-surgery.

CONCLUSION: Xanthomatous meningiomas, characterized by meningothelial and lipid-filled cells, remain a subject of limited research. Debates persist regarding the origin of the lipid-filled cells, whether it is from migrating macrophages or from degenerated meningothelial cells. The study highlights the epidemiology and differential diagnoses, emphasizing the importance of accurate histopathological and immunohistochemical examinations. Keywords : Xanthomatous meningioma, Systematic review, Meningioma, Skull base tumor