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¹Rutgers New Jersey Medical School Medicine, Department of Surgery, Newark, NJ, USA
²Cooper Medical School of Rowan University, Camden, NJ, USA
³Philadelphia College of Osteopathic Medicine, Department of Neurosurgery, Philadelphia, PA, USA
⁴Cooper University Hospital, Department of Neurosurgery, Camden, NJ, USA DOI : 10.5137/1019-5149.JTN.45375-23.2 Definitive diagnoses in neuro-oncology often require invasive procedures, such as surgical biopsies to obtain tissue for histopathologic and molecular interrogation. Patients with small lesions that may respond to nonsurgical treatments, such as chemoradiation, may nevertheless undergo surgery with potential risks to obtain diagnostic tissue. A means for noninvasively obtaining diagnostic information from brain tumors may improve patient care by limiting the need for surgery. Molecular evaluation of exosomes may provide such a means. Exosomes are small vesicles excreted from tumor cells that contain molecular information. Isolation of these vesicles from peripheral fluids, such as blood and urine, may provide diagnostic information for rendering a definitive diagnosis. Here, we review current clinical data for exosome-mediated brain tumor diagnostics. Keywords : NeuroOncology, Neurosurgery, Glioma, Liquid biopsy, Exosome, mRNA