Turkish Neurosurgery 2024 , Vol 34 , Num 3
Naples Prognostic Score Predicts 6-Month Outcomes in Patients with Severe Traumatic Brain Injury: A Single-Center Retrospective Study
Changcun CHEN1,Mingjiang SUN1,Yutong ZHAO1,Rui LIU1,Yuguang TANG1,Hao YANG2,Weiwei SHEN3,Zongyi XIE1
1Chongqing Medical University, The Second Affiliated Hospital, Department of Neurosurgery, Chongqing, People?s Republic of C
2Chongqing Medical University, The Second Affiliated Hospital, Department of Ultrasound, Chongqing, People?s Republic of China
3Chongqing Medical and Pharmaceutical College, The First Affiliated Hospital, Department of Endocrinology, Chongqing, People?s Republic of China
DOI : 10.5137/1019-5149.JTN.43209-22.3 AIM: To examine how Naples prognostic score (NPS) relates to 6-month outcomes in patients with severe traumatic brain injury (STBI).

MATERIAL and METHODS: We retrospectively analyzed the clinical data of 94 patients with STBI between September 2018 and September 2021. Galizia?s method was used to calculate NPS, and patients were categorized as high (NPS>3) or low (NPS?3) NPS according to their NPS scores based on receiver operating characteristic curve analysis. In addition, the controlling nutritional status score (CONUT) and prognostic nutrition index (PNI) were calculated. Based on the modified Rankin scale (mRS), the outcome for 6-months was evaluated. The mRS score for unfavorable outcomes was ?3.

RESULTS: In the univariate analyses, patients in the unfavorable group had higher NPS scores (p<0.001). The multivariate analysis demonstrated that NPS was an independent predictor of poor outcomes after adjusting for potential confounding factors (adjusted odds ratio = 7.463, 95% confidence interval [CI]: 1.131?49.253, p<0.05). The area under the NPS curve for predicting poor outcomes was 0.755 (95% CI: 0.655?0.837, p<0.001), which was significantly higher than Glasgow coma score (GCS), CONUT, and PNI (NPS vs. GCS, p=0.013; NPS vs. CONUT, p=0.029; NPS vs. PNI, p=0.015).

CONCLUSION: NPS can be considered to be a novel and better independent predictor of poor outcomes in patients with STBI. Keywords : Naples prognostic score, Severe traumatic brain injury, Immune-nutritional status, Prognosis

Corresponding author : Zongyi XIE, zyxie2008@cqmu.edu.cn