Turkish Neurosurgery 2024 , Vol 34 , Num 3
The Effect of Halofuginone Use on Epidural Fibrosis After Spinal Surgery: An Animal Experiment
Mehmet Zeki YILDIZ1, Baris PEKER2,Tugrul Cem UNAL3,Ilyas DOLAS3,Cafer Ikbal GULSEVER3,Duygu DOLEN4,Evren SONMEZ5,Yavuz ARAS3,Aydin AYDOSELI3,Pulat Akin SABANCI3,Altay SENCER3,Ali Nail IZGI3
1Bahcesehir University, Pendik Medical Park Hospital, Department of Neurosurgery, Istanbul, Türkiye
2Kagithane State Hospital, Department of Neurosurgery, Istanbul, Türkiye
3Istanbul University, Istanbul Faculty of Medicine, Department of Neurosurgery, Istanbul, Türkiye
4Yuksekova State Hospital, Department of Neurosurgery, Hakkari, Türkiye
5Health Sciences University, Kanuni Sultan Suleyman Training and Research Hospital, Department of Neurosurgery, Istanbul, Türkiye
DOI : 10.5137/1019-5149.JTN.42998-22.3 AIM: To investigate the effectiveness of local halofuginone application for spinal epidural fibrosis (EF) after lumbar laminectomy in rats.

MATERIAL and METHODS: Forty rats were equally divided into four groups (Groups I?IV; 10 rats in each group), and lumbar laminectomy was performed under general anesthesia. After laminectomy, Group I received saline (NaCl 0.9%) locally (control), Group II received spongostan, Group III received 0.5 mL of halofuginone-impregnated spongostan, and Group IV received 0.5 mL of halofuginone. Spongostan was used to prolong the exposure period of halofuginone. All rats were sacrificed after four weeks and evaluated according to histopathological criteria. A p-value of <0.05 was considered statistically significant.

RESULTS: Fibrosis was significantly lower in Group IV than in Group I (p<0.05). There was no significant difference in fibrosis between Group II/III and Group I. It was observed that spongostan increased fibrosis.

CONCLUSION: Halofuginone helps prevent EF after spinal surgery. However, further clinical and experimental studies are needed to assess its safety in humans. Keywords : Dura, Halofuginone, Fibrosis, Spinal surgery, Spinal cord, Rat

Corresponding author : Cafer Ikbal GULSEVER, cafer.gulsever@gmail.com