Turkish Neurosurgery 1995 , Vol 5 , Num 1-2
THE ROLE OF HYPERTENSION ON THE FORMATIAN OF CEREBRAL SACCULAR ANEURYSMS: AN EXPERIMENTAL STUDY IN RATS
Alper BAYSEFER1, Yusuf ERSAHİN1, Ferruh GEZEN1, K. Melih AKAY1, Ersin ERDOĞAN1, Cevat CAN2
1Departments of Neurosurgery, Gülhane Military Medical School Ankara – Türkiye
2Departments of Pathology Gülhane Military Medical School Ankara - Türkiye
The function of experimentally induced hypertension in the formation of saccular aneurysms in rats was the subject of this study. In four group of rats, the left common carotid artery and the posterior branch of both renal arteries was ligated in the first and third group, and only left common carotid artery in the second group. The fourth group was the control group and nothing was done. Rats in the second and third groups were given an injection of SC deoxycorticosterone acetate. There were offered standard drinking water was replaced by 1 % NaCl solution. Three months later, the rats were sacrificed by 10 % formol perfusion. Vessels with aneurysmatic appearance were examined using an operating microscope. Two aneurysms in the first group and four in the third were traced. The results show that saccular cerebral aneurysms are inducible in experimental animals. Keywords : Aneurysm Cerebral Aetiology Hypertension
Corresponding author : Alper Baysefer