Issue release date: 12.11.2024
2Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-oncology, Department of Neurosurgery, Jining, Shandong, P.R. China
3University of Virginia, Department of Radiology and Medical Imaging, Charlottesville, VA, USA DOI : 10.5137/1019-5149.JTN.34816-21.1 AIM: To review the correlation between vitamin D (VD) and several common neurological disorders with the aim of providing directions and ideas for using VD to treat neurological disorders.
MATERIAL and METHODS: VD, 1,25-dihydroxyvitamin D3, stroke, epilepsy, and cognitive dysfunction were used as keywords. The PubMed and Embase databases were searched for articles published from 2010 to 2021. The inclusion criteria were as follows: clear introduction of the research sample, detailed explanation of the sample selection in the research, intervention, and control measures, and available odds ratio and 95% confidence interval. The exclusion criteria were as follows: duplicate reports, defects in research design and poor quality, incomplete data and unclear results, and unmodifiable errors in the statistical method.
RESULTS: Initially, 1,360 articles were retrieved from the PubMed and Embase databases. Finally, 81 articles were included, 76 of which were published within the last 5 years.
CONCLUSION: VD deficiency is very common in the population and is associated with a variety of neurological diseases. VD, a neuroactive steroid, plays an important role in the protection of the central nervous system. In contrast, stroke can cause epilepsy and varying degrees of changes in cognitive function. Furthermore, seizure and epilepsy can cause changes in cognitive function. The degree of alteration in cognitive function affects the occurrence and progression of stroke and epilepsy. Therefore, VD can be used for the comprehensive treatment of neurological diseases.
Keywords : Vitamin D, Stroke, Cerebral apoplexy, Epilepsy, Cognitive impairment