Turkish Neurosurgery 2022 , Vol 32 , Num 2
A New Hope in the Treatment of Intraventricular Haemorrhage in Preterm Infants: Mesenchymal Stem Cells
Davut BOZKAYA1,Burak CERAN1,Esra OZMEN1,Esin OKMAN1,Evrim ALYAMAC DIZDAR1,Serife Suna OGUZ1,Ikbal OK BOZKAYA2
1Ankara City Hospital Child Health and Diseases, Division of Neonatology, Ankara, Turkey
2Ankara City Hospital Child Health and Diseases, Division of Pediatric Hematology, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.34850-21.2 To date, there has been no effective treatment to prevent brain damage in premature infants or to prevent the development of post-hemorrhagic hydrocephalus (PHH) after severe intraventricular hemorrhage (IVH). Therefore, new, safe and effective treatment methods need to be developed to improve the prognosis of IVH, for which morbidity and mortality rates are high. Recent studies have shown that the strong immunomodulatory properties of mesenchymal stem cells (MSCs) have an anti-inflammatory effect after IVH, inhibiting the development of PHH and decreasing apoptosis and gliosis, thus improving the self-renewal ability of neuronal tissues. For this reason, MSCs transplantation after IVH is a promising treatment method. In this article, we present a case of grade- III IVH who recovered after MSCs transplantation. Keywords : Intraventricular haemorrhage, Mesenchymal stem cells, Premature infant, Treatment
Corresponding author : Davut BOZKAYA, drbozkaya@gmail.com