Issue release date: 12.11.2024
2Istanbul Training and Research Hospital, Clinical Biochemistry Laboratory, Istanbul, Turkey
3Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Neurology, Istanbul, Turkey DOI : 10.5137/1019-5149.JTN.29081-20.4 AIM: To measure the serum levels of strong angiostatic and synaptogenetic molecules thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) in patients with temporal lobe epilepsy (TLE) before and after surgery.
MATERIAL and METHODS: In this prospective study, 20 patients operated for TLE and 20 healthy subjects were included. Serum levels of TSP-1 and TSP-2 were measured using enzyme-linked immunosorbent assay (ELISA).
RESULTS: Our findings showed that both groups had higher serum levels of both molecules ?before? surgery than 10 days ?after? surgery. However, a significant difference was noted between ?before? and ?after? surgery regarding TSP-1 (p=0.00001). Although a marked decrease was found ?after? surgery with respect to TSP-2, the difference did not reach statistical significance (p=0.22). In patients with TLE, serum levels of both molecules ?before? surgery were found to be significantly higher than in healthy controls (TSP-1, p=0.00001; TSP-2, p=0.007).
CONCLUSION: Serum levels of TSP-1 and TSP-2 are determined to be higher in patients with TLE than in healthy subjects, and the resection of epileptogenic tissues decreases the serum levels of these molecules. Future studies should involve a higher number of patients with serial serum levels of TSP-1 and TSP-2 at the long-term follow-up to correlate with seizure outcome.
Keywords : Angiogenesis, Seizure, Synaptogenesis, Temporal Lobe Epilepsy, Thrombospondin