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¹Çukurova University School of Medicine Department of Neurosurgery, Balcalı Adana Turkey
²Çukurova University School of Medicine Department of Histology, Balcalı Adana Turkey
³Çukurova University School of Department of Biochemistry, Balcalı Adana Turkey Although the main advantage of the CO₂ laser lies in the possibility of a less traumatic effect on the surrounding tissue, its use in neurosurgery still necessitates a thorough and detailed evaluation of the effect on surrounding normal central nervous system (CNS) tissue. Therefore this study was undertaken to investigate the ultrastructural and biochemical effects of the CO₂ laser on the application area and the surrounding normal central nervous system tissue. Sodium-potassium activated and magnesium-dependent adenosine-5'-triphosphatase (Na +-K + /Mg 2+ ATPase E.C.3.6.3.1) , magnesium dependent adenosine -5'-triphosphatase (Mg2+ ATPase E.C.3.6.1.3) and calcium activated magnesium dependent adenosine-5'-triphosphatase (Ca2+/Mg2+ ATPase E.C.3.6.1.3) enzymes, superoxide dismutase, light microscopic and ultrastructural findings were determined in dog brain following laser application with and without thyrotropin releasing hormone (TRH) treatment. Laser lesions were created by a CO₂ laser in the cerebrum. Fifteen days later, after thyrotropin releasing hormone injection, ultrastructural and biochemical investigations were undertaken to evaluate the effect of thyrotropin releasing hormone on the laser induced lesion and particularly surrounding cerebral tissue. Ultrastructural findings, showed that thyrotropin releasing hormone reduced degeneration on the CO₂ laser-applied lesion. Keywords : ATPase, CA2+/Mg2+, CO2 Laser, dog, Na+-K+/Mg2+ATPase, Mg2+ATPase, superoxide dismutase