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¹KTÜ, Faculty of Medicine Departments of Neurosurgery, Trabzon Türkiye
²KTÜ, Faculty of Medicine Departments of Histology, Trabzon Türkiye The effects of endothelin administered intravenously and intracerebroventricularly (i.c.v.) into the haematoma on arterial pressure, heart rate, other physiological parameters and intracerebroventricular haematoma were studied in the conscious rat. Control and intravenous (i.v.) endothelin-treated animals received 0.05 ml of normal saline injected into the clot, and the i.c.v. endothelin-treated group received an equal volume endothelin solution (10 nanogram) and i.v. endothelin-treated group received 2 ml endothelin solution (720 nanogram) intravenously. Intra- venous injection of endothelin (720nanogram/2 ml. 12 nanogram/minute i.v.) increased mean arterial pressure (MAP) and heart rate. But i.c.v. injection of endothelin (10 nanogram) produced tachycardia (p>0.05). By 24 hours. clot was lysed in 16.7 % of controls, in 42 .8% of i.v. endothelin-treated animals and in 62.8 of i.c.v. endothelin-treated animals. There was no significant difference in results of all groups for the lytic efficacy of both I.V, and I.C.V. endothelin injection. Keywords : Intracerebroventricular haematoma, Endothelin