Issue release date: 12.11.2024
Turkish Neurosurgery
1993 , Vol 3 , Num 4
INVESTIGATION OF SERUM AND TISSUE LIPID PEROXIDATION AND SERUM ASCORBIC ACID, AND IRON LEVELS IN HUMAN BRAIN TUMOUR
1Department of Biochemistry, School of Medicine Gazi University Ankara Türkiye2Department of Neurosurgery School of Medicine Gazi University Ankara Türkiye The present study aimed the biochemical relationships between human brain tumours and serum lipid peroxide, ascorbic acid and total iron levels. Tissue lipid peroxide levels in tumour tissue itself and in the surrounding tissue were also measured. Serum lipid peroxide levels were found to be significandy high (p<0.001) in patients with brain tumour while the serum ascorbic acid levels were significantly low (p<0.001) compared with the control group. Serum iron concentrations in patients with brain tumours were also found to be high but the results were nor statistically significant. On the other hand lipid peroxide levels in the turnour tissues were significantly lower than in the surrounding tissue (p<0.001).
We believe that high serum lipid peroxide levels in patients with brain tumours are the result of decreased serum ascorbic acid concentrations and the pressure effect of tumours on surrounding tissues which cause lipid peroxide levels in peripheral tissues and in the serum to increase.
Keywords : Ascorbic acid, Brain turnour, Iron, Lipid peroxidation