Issue release date: 12.11.2024
2Erciyes University Medical Faculty Biochemistry, Departments Kayseri, Türkiye
3Erciyes University Medical Faculty Pathology, Departments Kayseri, Türkiye Recent studies suggest that Nimodipine. a potent calcium-channel antagonist that causes significant cerebrovascular dilatation, may improve neurological outcome after acute experimental permanent focal cerebral ischaemia in animals when given before or immediately after occlusion of the middle cerebral artery (MCA).
In this study, the effect of Nimodipine and Mannitol, singly or in combination was investigated on focal cerebral ischaemia induced by MCA occlusion using the transorbital approach in the rabbit model. At 1 hour after occlusion, the rabbits were treated for 6 and 24 hours duration in a double-blind technique with either, sahne, nimodipine, mannitol and nimodipine + mannitol. Neurological outcome was better in rabbits treated with 6 and 24 hours nimodipine + mannitol at 1 hour after occlusion, and the size of areas of infarction was statistically the smailer in the nimodipine + mannitol treated group when compared with the controls. The degree of ischemic injury in the nimodipine+mannitol group was statistically reduced compared with the other groups. These results suggest that the possible mechanism of action of nimodipine + mannitol is on the "penumbra" of the ischaemic area.
Keywords : Mannitol, Nimodipine, cerebral ischaemia