The Preventative Effect of α-Tocopherol on Spinal Epidural Fibrosis After Laminectomy in a Rat Model

Cengiz TUNCER; Canan SUBASI; Cem DINC; Erhan TURKOGLU; Uygur ER

doi:10.5137/1019-5149.JTN.22357-17.5

Issue release date: 12.11.2024

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Turkish Neurosurgery 2019 , Vol 29 , Num 1

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The Preventative Effect of α-Tocopherol on Spinal Epidural Fibrosis After Laminectomy in a Rat Model

Cengiz TUNCER¹,Canan SUBASI¹,Cem DINC¹,Erhan TURKOGLU²,Uygur ER¹

¹Duzce University, School of Medicine, Department of Neurosurgery, Duzce, Turkey
²Yildirim Beyazit Training and Research Hospital, Neurosurgery Clinic, Ankara, Turkey DOI : 10.5137/1019-5149.JTN.22357-17.5 AIM: To assess the efficacy of α-tocopherol as a topical antifibrotic agent on epidural fibrosis in lumbar laminectomy procedures.

MATERIAL and METHODS: A total of 32 adult rats were assigned into four groups, with eight rats in each group. Standard laminectomy was performed in every rat. In group 1, no treatment was administered after laminectomy. In group 2, a saline-soaked absorbable gelatin sponge was left on the dura mater after laminectomy. In group 3, only α-tocopherol was used on the dura mater after laminectomy. In group 4, a gelatin sponge soaked with α-tocopherol was used after laminectomy. En bloc vertebral columns between T10 and L5 were removed after sacrifice on postoperative day 30. Specimens were evaluated for degree of fibrosis and arachnoidal invasions.

RESULTS: Statistically significant differences were found in the mean of fibrosis grades between groups (p=0.001). Differences in mean arachnoidal invasion were not statistically significant (p>0.05).

CONCLUSION: Topical application of α-tocopherol could effectively reduce the development of epidural fibrosis in an experimental laminectomy model. Keywords : ?-tocopherol, Laminectomy model, Postlaminectomy fibrosis, Vitamin E

Corresponding author : Uygur ER, uygurer@gmail.com