Issue release date: 12.11.2024

 
Turkish Neurosurgery 1993 , Vol 3 , Num 3
THE EFFECT OF DEFIBROTIDE ON CEREBRAL VASOSPASM FOLLOWING SUBARACHNOID HAEMORRHAGE: A LIGHT AND ELECTROMICROSCOPIC STUDY IN A 3-WAY SUBARACHNOID HAEMORRHAGE IN CATS
M. Memet ÖZEK1, İlker KAYABEYOĞLU1, M. Necmettin PAMİR1, Aydın SAV2, Nigar BAYKAN4, Türkan ERBENGİ3, Orhan ULUTİN5
1Marmara University School of Medicine Department of Neurosurgery, İstanbul Türkiye
2Marmara University School of Medicine Department of Pathology, İstanbul Türkiye
3Marmara University School of Medicine Department of Histology, İstanbul Türkiye
4Marmara University School of Medicine Department of Anaesthesiology, İstanbul Türkiye
5Marmara University School of Medicine Department of Haemostasis and Thrombosis Research Unit, İstanbul Türkiye Cerebral arterial vasospasm is the major complication of subarachnoid haemorrhage. This process of unclear aetiology causes significant increases in the morbidity and mortality of patients with subarachnoid haemorrhage. In this study all physiopathological characteristics of subarachnoid haemorrhage were established in a 3-way model in cats. Using this model, we investigated the efficacy of defibrotide in preventing cerebral arterial vasospasm following subarachnoid haemorrhage. A1though the process of vasospasm could not be prevented by the use of defibrotide, our results suggest that defibrotide can significantly decrease delayed histopathological damage after subarachnoid haemorrage. Keywords : Subarachnoid haemorrhage, Cerebral vasospasm, Defibrotide, Cerebral ischemia, Transient
Corresponding author : Memet Özek