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¹Department of Neurosurgery Hacettepe University Medical Faculty, Ankara, Türkiye
²Biochemistry Hacettepe University Medical Faculty, Ankara, Türkiye
³Turkish Organ Transplantation and Bum Foundation Hospital, Ankara, Türkiye In this study, Nd: YAG laser induced lipid peroxidation in spinal cord and the efficacy of alfa-tocoferol on this process were investigated. The study was performed on 36 adult guinea pigs divided into three groups. The first group was the control group and only laminectomy was performed. In the second group, using a Nd:YAG laser, focal spinal cord trauma was induced and lipid peroxidation values were measured in the first and sixth hours after the laser application. In the third group, alfa-tocoferol was administered intraperitoneally. 30 rninutes before the laser application and lipid peroxidation values were measured in the first and sixth hours after laser application. By comparing these results, statistical analysis revealed significant findings (For one hour U = 34. p<0.05; and for six hours U=36 p<0.05). This study showed that the application of 30 watt Nd:YAG laser irradiation for one second on spinal cord induced a significant value of lipid peroxidation in guinea pigs and alfa-tocoferol significantly protected secondary spinal cord damage by reducing the laser-induced lipid peroxidation levels. This means that alfa-tocoferol may have a potential role not only in the treatment oflaser-induced spinal trauma, but also in prophylaxis. Keywords : Alfa-tocoferol, YAG-Laser, Lipid Peroxides