Issue release date: 12.11.2024
Turkish Neurosurgery
1993 , Vol 3 , Num 2
Effects of Calcium Channel Blocker, Nicardipine, On Intracranial and Cerebral Perfusion Pressure in Experimental Intracerebral Haemorrhage
Department of Neurosurgery, Faeulty of Medidne, Akdeniz University, Antalya, Türkiye
Caldum channel blockers have an important role in the therapy of arterial hypertension and cerebral vasospasm. two phenomena which can be associated with intracerebral haematoma and increased intracranial pressure. The purpose of this study was to investigate the effec ts of Nicardipine on intracranial and cerebral perfusion pressure in animals with experimental intracranial haematoma formation. Cerebral perfusion pressure (CPP) was 75.12 5.11 mm Hg in the control group. Intracranial pressure(ICP) showed a significant increase with haematoma formation, but no significant difference was found in CPP, ICP and CPP did not show any significant difference in the group with slow infusion of nicardipine. However in the group with intravenous bolus application of nicardipine, there was a significant decrease in CPP.
In conclusion, with the use of calduro blockers for cerebral arterial vasodilatation, the increase in CBF and the antihypertensive effect might also be associated with some negative effects.
Keywords : Calcium Channel Blocker. Cerebral Haemorrhage. Cerebral perfusion pressure. Intracranial pressure