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İstanbul University, Cerrahpaşa Medical Faculty Department of Neurosurgery, Aksaray - İstanbul TURKİYE End-to-end anastomosis in the A. Carotis communis of rats (average diameter 0.8-1.0mm) was achieved using Nd-YAG laser. Morphological and histological findings of laser anastomosis and suture anastomosis specimens were compared by the LAMA technique. The rats were examined 1 day, 1 month and 2 months postoperatively. Macroscopic, angiographic, histological and SEM studies showed no development of pseudoaneurismus reported in previous studies. We conduded that laser anastomosis and vessel repair techniques caused less or minimal fibrotic reactions and minimized intraluminal thrombosis which itself means minimal haemodynamic disturbance. In addition, using a laser makes surgical manipulation that might be traumatising unnecessary and may be preferable to classical suture techniques. Keywords : Anastomosis, Nd- YAG laser, Microsurgery, Vascular surgery, Rat