THE EFFECT OF LIDOCAIN ON CEREBRAL BIOELECTRİC ACTIVITY AND ULTRASTRUCTURE IN FOCAL ISCHAEMIA

M. Memet ÖZEK; M. Necmettin PAMİR; A. Fahir ÖZER; Aykut ERBENGİ; Behsan ÖNOL; Turkan ERBENGİ

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Turkish Neurosurgery 1992 , Vol 2 , Num 4

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THE EFFECT OF LIDOCAIN ON CEREBRAL BIOELECTRİC ACTIVITY AND ULTRASTRUCTURE IN FOCAL ISCHAEMIA

M. Memet ÖZEK¹, M. Necmettin PAMİR¹, A. Fahir ÖZER¹, Aykut ERBENGİ³, Behsan ÖNOL⁴, Turkan ERBENGİ²

¹Marmara University School of Medicine Department of Neurosurgery, İstanbul- TÜRKİYE
²Marmara University School of Medicine Department of Histology, İstanbul- TÜRKİYE
³Hacettepe University School of Medicine Department of Neurosurgery, Ankara – TÜRKİYE
⁴Hacettepe University School of Medicine Department of Pathology, Ankara - TÜRKİYE In this study. we evaluated whether Lidocain would reduce ischaemic brain damage and restore bioelectric activity in cats subjected to permanent unilateral occlusion of the middle cerebral artery.

In the Lidocain treated group there was a statistically significant improvement in the latendes and amplitudes of somatosensory evoked potentials. The treated group showed also a more limited infarct area on the coronal brain sections. Light and electrone microscope examination revealed that the histopathological infarct process was delayed in the treated group. Keywords : Focal brain ischaemia. Cerebral infarction. Lidocain. Somatosensory evoked potentials

Corresponding author : M. Memet Özek