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İstanbul University Cerrahpaşa Medical Faculty Department of Neurosurgery İstanbul – TÜRKİYE In this study, 21 patients between the ages of 40 and 75 (mean age 61) who were within the first 48 hours of acute ischaemic stroke were included. Isovolaemic haemodilution with Dextran 40 (rheomacrodeks) was applied, the mean Htc value was 43 +-4.8 (38-55) before treatment. After five days of haemodilution therapy, the value descended to 35 +-2 which is a significant change. The ratio of neurological deficits also showed a decrease. Improvement in EEG findings and P02 levels observed were not considered significant. No complications were observed during the treatment. Keywords : Brain ischaemia, Cerebral blood flow, Dextran, Haemodilution