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Fudan University, Zhongshan Hospital, Department of Neurosurgery, Shanghai, China DOI : 10.5137/1019-5149.JTN.6430-12.0 The aim of this report was to summarize our preliminary experience on the resection of tumors located in Meckel’s cave via the endoscopic endonasal transmaxillary transpterygoid approach with image-guided system and to investigate the feasibility and efficacy of this approach. Two patients who had tumors in left Meckel’s cave underwent surgical treatment using the image-guided endoscopic endonasal transmaxillary transpterygoid approach. This particular technique has advantages of no brain retraction, direct vision of tumor resection and protection of surrounding neurovascular structures. Neuronavigation increases the safety of the endoscopic approach. Keywords : Meckel’s cave, Endoscopic approach, Neuronavigation