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¹Karadeniz Technical University Medical Faculty Departments of Neurosurgery, Trabzon-TÜRKİYE
²Karadeniz Technical University Medical Faculty Departments of Pathology, Trabzon-TÜRKİYE In an attempt to investigate the effect of tissue plasminogen activator in the resolution of intracerebral haematoma an experimental model of intracerebral haematoma was designed in the cat. A total of 24 adult cats were studied. Intracerebral hematomas were provoked by stereotaxically injecting 0.2 ml of dotted human blood into the left frontal lobe. Control animals received 0.2 ml of normal saline injected into the dot and the experimental group received 0.2 ml of tissue plasminogen activator solution (3750 unite/ml). Six hours after injection, dot lysis was demonstrated in 11 (84,6%) of 13 tissue plasminogen activator-treated animals and 1 (5.5%) of 11 controls (p <0.001). Tissue plasminogen activator did not cause inflammation or bleeding in the epandyma or parenchyma except in the perihaematomal parenchyma. Keywords : Intracerebral Haematoma. Tissue Plasminogen Activator, Cat