Turkish Neurosurgery 2014 , Vol 24 , Num 6
Endoscopic Endonasal Transsphenoidal Treatment for Acromegaly: 2010 Consensus Criteria for Remission and Predictors of Outcomes
Ali Erdem YILDIRIM1, Mert SAHINOGLU1, Denizhan DIVANLIOGLU1, Fatih ALAGOZ1, Ahmet Gurhan GURCAY2, Ergun DAGLIOGLU1, Hilmi Onder OKAY3, Ahmed Deniz BELEN1
1Ankara Numune Research and Education Hospital, Department of Neurosurgery, Ankara, Turkey
2Ankara Ataturk Research and Education Hospital, Department of Neurosurgery, Ankara, Turkey
3Erzurum Research and Education Hospital, Department of Neurosurgery, Erzurum, Turkey
DOI : 10.5137/1019-5149.JTN.11288-14.1 AIM: Acromegaly is a chronic disorder characterized by enhanced growth hormone (GH) secretion and elevated insulin-like growth factor–I (IGF-I) levels, usually caused by pituitary adenomas. In this retrospective study, we reviewed our experience with endoscopic endonasal transsphenoidal surgery (EETS) with in remission rates using the 2010 consensus criteria, predictors of remission and associated complications.

MATERIAL and METHODS: The authors retrospectively analyzed data from 56 acromegalic patients who underwent pure EETS. Tumors were classified according to size and suprasellar/parasellar extension. The criteria of remission were GH levels < 1 ng/mL randomly, < 0.4 ng/mL after oral glucose tolerance test and normal IGF–I levels for age and sex within the first 3 and 6 months after surgery.

RESULTS: Biochemical remission was achieved in 4 of 5 microadenomas (80%) and in 33 of 51 macroadenomas (64.7%). The total remission rate was 66.1% (37 of 56 adenomas). Age, gender and suprasellar extension did not affect the remission rate. However, cavernous sinus invasion, sphenoid sinus invasion and history of prior surgery were associated with lower rates of disease control.

CONCLUSION: EETS represents an effective and safe option for the treatment of patients with acromegaly. High disease control rates and a small number of complications are some of the most important points related to the technique. Keywords : Acromegaly, Endoscopic transsphenoidal surgery, Remission, Predictive factors

Corresponding author : Ali Erdem Yıldırım, alierdemyildirim@gmail.com