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¹University of Messina, Department of Neurosurgery, Messina, Italy
²University of Palermo, Faculty of Medicine, Neurosurgical Clinic, Department of Experimental Biomedicine and Clinical Neurosciences, Palermo, Italy DOI : 10.5137/1019-5149.JTN.7049-12.0 Cranial and intracranial involvement by myelomatous disease is relatively uncommon. Furthermore, systemic manifestations of multiple myeloma are present in the majority of these cases at the time of symptom onset. The authors report the case of a patient with serial appearance of multiple intracranial plasma cell tumor localizations as the first manifestations of a multiple myeloma. The patient was treated with CyberKnife radiosurgery for a lesion localized at the clivus and sella turcica with complete local control. With such a technique, based on high-dose conformality, the tumor was centered with an ablative dose of radiation and, at the same time, with a low dose spreading to the surrounding critical structures. The radiosensitivity of plasma cell tumors renders this treatment modality particularly advantageous for their localized manifestation. A technical description of this case is provided. To our knowledge, this is the first case of successful Cyberknife radiosurgery of multifocal intracranial plasmacytoma. Keywords : Radiosurgery, Cyberknife, Plasma cell tumor