Issue release date: 12.11.2024
2Istanbul University, Cerrahpasa Medical Faculty, Department of Anesthesiology, Istanbul, Turkey
3Istanbul University, Cerrahpasa Medical Faculty,Department of Neurosurgery, Istanbul, Turkey DOI : 10.5137/1019-5149.JTN.8218-13.0 AIM: This study aims to evaluate how analgesia-sedation causes alterations of HLA-DR and cytokines (IL-10 and IL-6) in patients undergoing cerebral angiography for several cerebral vascular diseases.
MATERIAL and METHODS: This study includes 41 males who underwent cerebral angiography. The study sample was divided into two: Group I had 7 patients who did not receive and group II had 34 patients who received analgesia-sedation before cerebral angiography. A venous blood sample was collected before and after cerebral angiography.
RESULTS: Analgesia-sedation caused significant increase CD4+ and CD19 T lymphocytes (p < 0.001) but group I showed significant increase in CD40, CD154, and MHC-II levels (p < 0.001) after cerebral angiography.
CONCLUSION: We suggest that the effects of fentanyl and midazolam on the immune response are the reflection of the effects by the monocyte, mHLA-DR expression. In the future, depending on the immunological status of the patients, different anesthetic applications including the new anesthetic agents that will be able to decrease immune system suppression will be required.
Keywords : Analgesia, Anesthesia, HLA-DR, Monocyte, Sedation