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University of Hacettepe Institute of Neurological Sciences and Psychiatry Sıhhiye 06100 ANKARA Cladosporium trichoides is a rarely seen fungal infection of the central nervous system. Since spores are found in nature, the portal entry is still obscure. It has a strong neurotropism which has been proved in experimental studies. In a modified LEVINE preparation, the effects of mannitol. In the central nervous system it mostly produces brain abscess, in some cases multiple. The prognosis is bad in the majority of cases. Fluocytosine seems useful in conjunction with surgery. Keywords : Cladosporiosis. Fungal cerebral abscees