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Second Affiliated Hospital, College of Medicine, Zhejiang University, Department of Neurosurgery, Hangzhou, China DOI : 10.5137/1019-5149.JTN.3597-10.1 Multiple spinal extradural arachnoid cysts (SEACs) are relatively rare lesions, which may cause symptoms due to spinal cord compression. Radical resection of multiple SEACs during one-stage surgery is the primary treatment for the rare lesion, because of its effective and safe operation. Here, we present a 13-year-old female, who presented with a 3-month history of progressive weakness in the right leg. For the first time, we reported partial resection of multiple SEACs without treating the other parts, can also lead to a favorable outcome. No change in the cysts and spinal deformity were observed during a follow-up period of 5 years. Keywords : Extradural arachnoid cyst, Spinal cord compression, Magnetic resonance imaging (MRI)