Turkish Neurosurgery 2012 , Vol 22 , Num 6
The Therapeutic Effects of Melatonin and Nimodipine in Rats after Cerebral Cortical Injury
Ozgur ISMAILOGLU1, Pergin ATILLA3, Selcuk PALAOGLU2, Nur CAKAR3, Umit YASAR4, Kamer KILINC5, Erkan KAPTANOGLU6
1Suleyman Demirel University, Medical Faculty Hospital, Department of Neurosurgery, Isparta, Turkey
2Hacettepe University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey
3Hacettepe University, Faculty of Medicine, Department of Histology & Embryology, Ankara, Turkey
4Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
5Hacettepe University, Faculty f Medicine, Department of Biochemistry, Ankara, Turkey
6Yakin Dogu University, Faculty of Medicine, Department of Neurosurgery,Cyprus, Republic of Turkish
DOI : 10.5137/1019-5149.JTN.6197-12.1 AIM: Secondary brain injury starts after the initial traumatic impact and marked by an increase in the intracellular calcium concentrations.This cascadeeventually results in membrane lipid peroxidation and neuronal cell death.

MATERIAL and METHODS: We investigated the neuro-protective effects of nimodipine and melatonin in 38 rats after 6 hours of head trauma using the cortical impact injury model of Marmarou.

RESULTS: Brain water in the melatonin-given group decreased significantly comparing to that of control group the brain water in the nimodipine given group increased significantly comparing to that of trauma group. Histopathologically, brain edema was significantly low in melatonin-administered group comparing to that of control group while there were no changes in brain edema in the nimodipine given group and in the group that both nimodipine and melatonin were administered in combination. MDA levels in the brain tissues were significantly lower in the melatonin and nimodipine groups comparing to those of trauma and control group however this difference was by far significant in melatonin group comparing to nimodipine group.

CONCLUSION: Melatonin appears to have neuro-protective effects on the secondary brain damage while nimodipine and nimodipine plus melatonin combination did not show such neuro-protective effects on the secondary brain injury. Keywords : Melatonin, Nimodipine, Head trauma, Rat

Corresponding author : Ozgur Ismařloglu, ozguri_36@hotmail.com