Issue release date: 08.03.2024
2Acibadem University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Istanbul, Turkey
3Marmara University, Faculty of Medicine, Department of Pathology, Istanbul, Turkey
4Marmara University, Faculty of Medicine, Department of Histology and Embryology, Istanbul, Turkey
5Marmara University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey
6Acıbadem University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey DOI : 10.5137/1019-5149.JTN.3523-10.2 AIM: Aim of this study is to assess effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury.
MATERIAL and METHODS: For 5 days after SCI rats were received saline in group C and Omegaven in group O. Locomotor strengths (BBB scale)of animals were rated at Day 0,7,14,21,28, and 35. At Day 35 spinal cord sampling was evaluated immunohistochemically.
RESULTS: BBB scores were 0 in early period after SCI was inflicted in both groups. BBB scores were progressively increased after Day 7 in both groups (p<.005). BBB scores were significantly higher in group O when compared with control group after Day7 in all times (p<.005). Neuronal injury (p<.002) and edema was much more in control group when compared with in group O (p<.005). Scores for white mater cavitation, demyelinization and vessel in growth were similar in both groups. VEGF expression in control group was higher (p=.019).
CONCLUSION: At the early period of SCI fish-oil emulsion treatment in rats, its anti-inflammatory effects leaded to decrease in edema and had positive effect at the prevention of neuronal injury. We believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.
Keywords : Omega-3 fatty acids, Omega-6 fatty acids, Neuron recovery, Nutrition, Spinal cord injury