Turkish Neurosurgery 2017 , Vol 27 , Num 2
Gamma Knife Radiosurgery for Arteriovenous Malformations: Clinical Series of 199 Patients
Ipek ARSLAN1,Evrim TEZCANLI2,Meltem YILMAZ3,Olcay CIZMELI4,Meric SENGOZ2,Selcuk PEKER5
1Gaziosmanpasa University, Department of Radiation Oncology, Tokat, Turkey
2Acibadem University, Department of Radiation Oncology, Istanbul, Turkey
3Acibadem Kozyatagi Hospital, Department of Radiation Oncology, Istanbul, Turkey
4Acibadem University, Department of Radiology, Istanbul, Turkey
5Acibadem University, Department of Neurosurgery, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.15330-15.0 AIM: Cerebral arteriovenous malformations (AVM) are pathological connections between arteries and veins without capillaries. Stereotactic radiosurgery (RS) is a proven and accepted treatment method for cerebral AVMs. Our objective was to analyze the factors influencing the clinical outcome in patients suffering from AVMs.

MATERIAL and METHODS: We retrospectively reviewed 199 patients who were treated with Gamma-Knife RS for intracranial AVMs between 13 October 2005 and 31 October 2010. There were 89 male, 110 female patients with a median age of 32 years (range, 3-74 years). Obliteration was assessed with MRI angiography and DSA imaging.

RESULTS: Complete obliteration rate after RS was 71 % (141 out of 199), including second RS treatments. In terms of obliteration rates, there was no significant difference between patients younger and older than 21 years old (p=0.669). After RS, 3 patients died due to intracranial hemorrhage and 1 died of heart disease. Death from AVM was determined as 1.5 %. Intracranial hemorrhage was observed in 7 (3.5 %) patients post-RS.

CONCLUSION: Obliteration was found to be associated with Spetzler-Martin Grade, Pollock-Flickinger Grade, AVM volume, RS dose, bleeding history before RS and no previous embolization before RS. Gamma knife RS is an effective treatment method for the treatment of AVMs both for pediatric and adult patients. It provides high obliteration and low mortality rates. Keywords : Arteriovenous malformations, Radiosurgery, Gamma Knife