Effect of Asiatic Acid on the Treatment of Spinal Cord Injury: An Experimental Study in Rats
AIM: Spinal cord injury (SCI) is a devastating condition of the central nervous system. There is no proven therapeutic agent for
the treatment of this complex disorder. Asiatic acid (AA) has been used as an anti-inflammatory and anti-oxidant agent in Eastern
countries for many years. The aim of this study was to investigate the effectiveness of AA on the treatment of traumatic SCI in rats.
MATERIAL and METHODS: Thirty-two adult male Sprague-Dawley rats were divided into 4 groups as laminectomy,
laminectomy+trauma, vehicle, and AA treatment groups. SCI was created by the modified Allen"s weight-drop technique. After the
injury, the levels of pro-inflammatory cytokines (IL-6, IL1-Β, TNF-α) and lipid peroxidation products (MDA) were measured. Tarlov
functional recovery scores were also determined for each rat.
The One-way ANOVA test was used for the analysis of difference between 4 experimental groups and the groups were compared
individually by Tukey-LSD post hoc analysis test (p=0.001).
RESULTS: AA administration just after SCI attenuated the levels of lipid peroxidation products (MDA) and pro-inflammatory
cytokines (TNF-α, IL1Β). It also increased the Tarlov functional recovery scores of the rats.
CONCLUSION: AA administration could attenuate a number of deleterious reactions after traumatic SCI. Further studies are needed
to elucidate the pathways of neuroprotective effects of AA after spinal trauma.